Submental fat, the pocket of fat under the chin, is one of the most stubbornly genetic fat deposits on the body. It is not caused by weight gain alone.
Plenty of people who are lean and fit carry it because of facial anatomy and genetics. And no exercise targets it, because you cannot spot-reduce fat with movement.
If you have tried everything and that pocket of fat under your chin remains, there is actually a science-backed answer now, and it has been available since 2015.
What Kybella Is and How It Works
Kybella is an FDA-approved injectable treatment containing synthetic deoxycholic acid. Deoxycholic acid is a naturally occurring molecule in the body that aids in the breakdown and absorption of dietary fat.
When injected into submental fat, it disrupts the cell membrane of fat cells, causing them to break down and be metabolized by the body over the following weeks.
The pivotal clinical trials for Kybella (ATX-101) were published in JAMA Dermatology and demonstrated that 68.2% of patients in the treatment group achieved a clinically meaningful reduction in submental fat compared to 20.5% in the placebo group. Patient satisfaction scores were significantly higher in the treated group, and the improvements were maintained at 12-month follow-up.
This is not a temporary treatment. Once a fat cell is destroyed, it cannot regenerate.
The fat in the treated area is gone permanently, which makes Kybella different from most aesthetic treatments that require ongoing maintenance.
What to Expect from Treatment and Recovery
Each Kybella session involves a grid of small injections placed precisely in the submental fat pocket. The procedure takes approximately 20 minutes.
The injections cause a brief burning sensation that subsides quickly.
Here is the honest part: the swelling is significant. Kybella causes inflammatory destruction of fat cells, and the area under the chin will be noticeably swollen for 5 to 10 days after each session.
Some patients experience numbness, firmness, or bruising as well, all of which resolve as the tissue heals. This is not a treatment to schedule before a beach vacation or important event.
Most patients see meaningful improvement after 2 to 4 sessions spaced at least 4 to 6 weeks apart. Maximum results appear approximately 4 to 6 weeks after the final session, once all the destroyed fat cells have been cleared from the tissue.
Is the Result Actually Permanent?
Yes, within the treated area. Destroyed fat cells do not return.
However, if you gain a significant amount of weight after treatment, remaining fat cells in the area can enlarge, and fat can also accumulate in adjacent areas. Most patients maintain their results long-term with a stable weight.
Kybella vs. CoolSculpting for the Chin
CoolSculpting (cryolipolysis) is the other non-surgical fat reduction option. For the submental area specifically, Kybella tends to be more precise and predictable because it treats the full pocket of fat regardless of shape or accessibility, and it produces more consistent results across a range of submental anatomy.
CoolSculpting works well for the chin area but requires a specific applicator fit, which does not suit every anatomy.
The best way to know which fits you is an in-person consultation where we assess your anatomy and fat distribution directly.
Are You a Good Candidate?
Good candidates for Kybella have:
- Moderate to significant submental fat that has not responded to diet and exercise
- Good skin elasticity (so skin contracts after fat reduction rather than appearing loose)
- Realistic expectations about the number of sessions needed
- Flexibility in their schedule to accommodate the recovery window after each session
If submental fat is mild and skin laxity is a significant concern, Morpheus8 might be a better starting point, as it addresses both the subdermal fat layer and skin tightness simultaneously.
Tired of a double chin that does not reflect how you actually feel? Come in for a complimentary consultation. We will assess your anatomy and tell you honestly whether Kybella, CoolSculpting, or another approach is the right fit for your goals.
Book a ConsultationReferences
- Rzany B, et al. Efficacy and safety of injectable ATX-101 for reduction in submental fat: evidence from a phase III, randomized, placebo-controlled, multinational study. JAMA Dermatol. 2014;150(12):1294-1301.
- Ascher B, et al. Injectable deoxycholic acid for the reduction of submental fat: a phase III randomized controlled trial. J Drugs Dermatol. 2016;15(7):839-847.
- FDA. Kybella (deoxycholic acid injection) prescribing information. 2015.